A Clinical Protocol to Validate a Breast Conservative Therapy Outcome Model
Lepoutre, Nicole G 1990-
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Breast cancer is the most common cancer among women around the world. Regarding the different treatments modalities for breast cancer, one is Breast Conservative Therapy (BCT) where the complete tumor and a margin of healthy tissues are surgically removed and the remaining breast tissue receives radiotherapy. From a patient point of view, preserving the shape of her breast is essential for her quality of life and hence, BCT may be a good treatment option. Although the outcome of this treatment usually provides good clinical results, some cosmetic defects like asymmetry may emerge. The goal of our team is to offer surgeons a tool that predicts the shape of the breast after BCT. Therefore, a multiscale model has been implemented by members of our team and is being validated and fine-tuned. A clinical study has been designed. The objective of this Master's thesis is to determine whether the predicted shape of the breast is realistic or not by: - acquiring numerical data during the patients' follow-up, - providing a confident 3D-reconstruction of the breast at certain point in time, - understanding the main steps during the healing process.