Effects of Compensatory Mutations on Evolved Strains of Antibiotic Resistant E.coli
MetadataShow full item record
Pathogens that are exposed to antibiotics acquire mutations that confer resistance. In the absence of antibiotics resistant mutants have a lower fitness relative to their sensitive ancestral strain. Fitness costs associated with resistance are often ameliorated through the acquisition of compensatory mutations. To test how compensatory mutation depend on resistance mutations I selected for strains resistant to the common antibiotics trimethoprim and sulfamethoxazole and tracked the evolution of compensation.