Cannabis Terpenes Synergistically Modulate Hippocampal Excitability
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This work demonstrates how commonly ingested aromatic compounds (terpenes, flavonoids, and odorants) can induce physiological changes on the molecular level in brain regions implicated in high order information processing. Indeed, the component discussed in this study (BCP) is found in relatively high concentrations in common household spices such as cloves and black pepper. Also, limonene is commonly found in the rinds of citrus fruits (e.g. lemon and oranges). These physiological actions could be responsible for individual preferences of different types of foods and aromas that act synergistically with our bodies and modify behavior. Lastly, the need for effective treatments for severe pharmacoresistant forms of pediatric epilepsies such as Dravet syndrome is of imminent importance. Due to current drug laws, it is legally and financially impractical for many people to obtain high quality and high concentration C. sativa extracts. This could lead to ingestion of inferior products with chemical contamination or highly variable concentrations of chemical components. This issue may be completely circumvented by using natural non-cannabis derived cannabinoid agonists. The only limitation is our lack of knowledge and testing regarding these substances.