Show simple item record

dc.contributor.advisorMassman, Paul J.
dc.creatorTravis Seidl, Jennifer N
dc.date.accessioned2015-08-28T02:00:46Z
dc.date.available2015-08-28T02:00:46Z
dc.date.createdMay 2015
dc.date.issued2015-05
dc.identifier.urihttp://hdl.handle.net/10657/1117
dc.description.abstractPrevious research has demonstrated an association between the emotional and behavioral symptoms of dementia, known as neuropsychiatric symptoms, and cognitive and functional decline among patients with Alzheimer’s disease (AD). The present study aimed to identify baseline associations, as well as relationships over time, between neuropsychiatric symptoms and cognitive and functional performance. Participants were 288 AD patients enrolled in the Alzheimer’s Disease and Memory Disorders Center (ADMDC) at Baylor College of Medicine. An exploratory factor analysis of a measure of neuropsychiatric symptoms, the Neuropsychiatric Inventory-Questionnaire (NPI-Q), indicated a two-factor structure consisting of Negative/Oppositional and Anxiety/Restlessness factors. At an initial evaluation, regression analyses revealed significant associations between greater total severity of neuropsychiatric symptoms and poorer performance on measures of overall dementia severity, immediate verbal recall, and basic and instrumental activities of daily living (ADLs). Greater severity of Anxiety/Restlessness symptoms was associated with poorer performance on measures of overall dementia severity, executive functioning, visuospatial functioning, and basic and instrumental ADLs. The Negative/Oppositional factor was not related to cognition or functioning. Greater initial neuropsychiatric symptom severity was also associated with worsening overall dementia severity over time. Worsening severity of neuropsychiatric symptoms over time, and particularly worsening of Anxiety/Restlessness symptoms, were related to worsening overall dementia severity over time, as well as a deceleration of overall dementia severity progression. In summary, neuropsychiatric symptoms (particularly Anxiety/Restlessness symptoms) were related to cognition, everyday functioning, and decline over time. Proper assessment and treatment of these symptoms is essential for improving cognition and functioning in AD patients.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectAlzheimer's disease
dc.subjectneuropsychiatric symptoms
dc.subjectneuropsychological testing
dc.subject.lcshClinical psychology
dc.titleCognitive correlates of neuropsychiatric syndromes measured over time in patients with Alzheimer's disease
dc.date.updated2015-08-28T02:00:46Z
dc.type.genreThesis
thesis.degree.nameDoctor of Philosophy
thesis.degree.levelDoctoral
thesis.degree.disciplinePsychology, Clinical
thesis.degree.grantorUniversity of Houston
thesis.degree.departmentPsychology, Department of
dc.contributor.committeeMemberTian, T. Siva
dc.contributor.committeeMemberWalker, Rheeda
dc.contributor.committeeMemberDulay, Mario F., Jr.
dc.type.dcmiText
dc.format.digitalOriginborn digital
dc.description.departmentPsychology, Department of
thesis.degree.collegeCollege of Liberal Arts and Social Sciences


Files in this item


Thumbnail

This item appears in the following Collection(s)

Show simple item record