Wu, Tianfu2018-11-302018-11-30May 20182018-05May 2018http://hdl.handle.net/10657/3506Antigen microarray is a high-throughput technology, which can be used to select potential biomarkers. In this paper, antigen microarray is the main technology used to determine potential autoantibody biomarkers in different diseases: psoriasis and breast cancer. IgG subtype and IgG total were used as secondary antibodies to bind autoantibodies in patients’ serum, for psoriasis and breast cancer respectively. The enzyme-linked immunosorbent assay (ELISA) was adopted to measure serum level of the potential autoantibodies in a large number of serum samples from patients and healthy controls. These studies have revealed IgG4 anti-human gliadin autoantibody as a potential novel biomarker of psoriasis.application/pdfengThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).Antigen arrayPsoriasisBiomarkers2018-11-30Thesisborn digital