Piety, Nathaniel Z.Yang, XiaoxiKanter, JulieVignes, Seth M.George, AlexShevkoplyas, Sergey S.2020-03-102020-03-101/6/2016Copyright 2016 PLoS. Recommended citation: Piety, Nathaniel Z., Xiaoxi Yang, Julie Kanter, Seth M. Vignes, Alex George, and Sergey S. Shevkoplyas. "Validation of a low-cost paper-based screening test for sickle cell anemia." PLoS One 11, no. 1 (2016): e0144901. DOI: 10.1371/journal.pone.0144901 URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144901&type=printable Reproduced in accordance with the original publisher’s licensing terms and with permission from the author(s).https://hdl.handle.net/10657/6168The high childhood mortality and life-long complications associated with sickle cell anemia (SCA) in developing countries could be significantly reduced with effective prophylaxis and education if SCA is diagnosed early in life. However, conventional laboratory methods used for diagnosing SCA remain prohibitively expensive and impractical in this setting. This study describes the clinical validation of a low-cost paper-based test for SCA that can accurately identify sickle trait carriers (HbAS) and individuals with SCA (HbSS) among adults and children over 1 year of age.en-USBloodHemoglobinSickle cell diseaseDiagnostic medicineSolubilityNeonatesAngolaCell stainingarticle