Kimball, Aubrey P.2022-09-232022-09-231970197023157061https://hdl.handle.net/10657/11945This study is concerned with the oxidation product of 9-ß-D-ribosyl-6-methylthiopurine. The oxidation product was synthesized in several steps from inosine. 6-mercaptopurine riboside was radiolabeled using sulfur-35. The kinetic study of the sulfur-35 exchange was studied. Methylation and oxidation yielded the 9-ß-D-ribosyl-6-methylthiopurine oxidation product. The radiolabeled product was used to study decomposition of the drug in solution as well as binding of the drug to amino acids.application/pdfenThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.ß-D-ribosyl-6-methylthiopurineThesisreformatted digital