Kay, Franklin J.2022-10-142022-10-141972197213806234https://hdl.handle.net/10657/12341A mathematical model and digital computer simulation of the human cardiovascular system and its controls are developed to simulate transient responses to bicycle ergometer exercise. The purpose of the model is to provide a method to analyze cardiovascular control hypotheses which cannot be easily tested in an animal or human. Complex cardiovascular control hypotheses are derived for the control of heart period, peripheral flow resistances, venous tone, and other controlled variables. Control models are based on the use of proportional neurogenic controllers and linearized system elements where possible. Metabolic control models are also derived using simple mathematical models of oxygen uptake, oxygen deficit, and accumulating metabolites to indicate the transient metabolic state and simulate other chemical factors. Equations describing pulsatile blood flows, pressures, and volumes for 28 model sections of the uncontrolled cardiovascular circulatory system are solved. The circulatory system model is combined with the models of the controlling systems to simulate transient responses to exercise. Other characteristics of the combined model include gravity effects, muscle pumping, venous tone, venous valves, respiratory frequency, and intrathoracic pressure effects. Results of simulation tests are described for resting conditions, zero load pedaling, and four levels of exercise. Transient response characteristics and steady model values are presented and compared with experimental data. It is concluded that the neurogenic proportional controller hypothesis, combined with the metabolic control factors, can satisfactorily simulate submaximal exercise responses.application/pdfenThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.Thesisreformatted digital