Gilbertson, Scott R.2017-07-252017-07-25May 20152015-05May 2015Portions of this document appear in: Zhao, Yang, and Scott R. Gilbertson. "Synthesis of Proline-Based N-Heterocyclic Carbene Ligands." Organic letters 16, no. 4 (2014): 1033-1035. The material from this article is from the accepted manuscript of a published work that appeared in final form in Organic Letters. The version of record for that article is available at the following DOI: 10.1021/ol403465d.http://hdl.handle.net/10657/1936The synthesis of novel proline-based N-heterocyclic carbene ligands has been accomplished. These types of imidazolium salts can be used as building blocks for the synthesis of more sophisticated N-heterocyclic carbene precursors. The proline amino acids are shown to be compatible with peptide synthetic methods by incorporation into tripeptides. The approaches to a variety of bidentate ligand precursors was reported. A number of the ligands synthesized were bound to rhodium through transmetallation of a silver-NHC complex.application/pdfengThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. UH Libraries has secured permission to reproduce any and all previously published materials contained in the work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).SynthesisN-heterocyclic carbeneAmino acidPeptideLigandsCatalysis2017-07-25Thesisborn digital