Mailman, David S.2022-07-072022-07-07197117972007https://hdl.handle.net/10657/10429In general norepinephrine (NE) exhibits antagonistic effects to that of antidiuretic hormone (ADH) with respect to renal salt and water excretion. This was demonstrated by infusing ADH intravenously at rates of 0, 5, and 25, uU/kg/min in three different groups of mongrel dogs which were chemically sympathectomized with guanethidine sulfate. Within each, group infused with constant levels of ADH, NE was infused at increasing rates from 0.05 to 3.2 ug/kg/min during eight consecutive thirty minute periods. Under these conditions NE was diuretic, natriuretic, and increased both osmolar and free water clearance, while ADH had the opposite effects. These effects of NE appear to be the result of decreased permeability of the collecting duct first to solutes and second to water.application/pdfenThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.Thesisreformatted digital