Mohan, Chandra2020-01-04May 20192019-05May 2019https://hdl.handle.net/10657/5741Discovery of therapeutic or biotechnological agents is crucial in aiding the research of disease therapy. This thesis entails two projects, the first project focuses on utilizing a magnetic screening-based assay to identify peptoid-based compounds from a one-bead-one-compound (OBOC) library with specificity to human C-reactive protein, four initial hits were found, which was then repeated with a quantum dot assay that did not confirm binding of the hits to CRP due to technical concerns. The second project takes a peptoid-based hit GUCM-1 discovered from a previous screening assay with specificity for toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), an adaptor protein with a crucial role in the toll-like receptor 4 (TLR4) signal transduction pathway and studied it for its functional effects on a human myeloid cell line, results were inconclusive and further studies are needed to validate these findings.application/pdfengThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).PeptoidOne-bead-one-compound (OBOC)ScreeningTLR4TIRAPToll-like receptorsMAL2020-01-04Thesisborn digital