Ott, WilliamKaramched, BhargavLam, Tammy2021-02-112021-02-112020-09-29https://hdl.handle.net/10657/7467The dynamics of physiological systems are significantly impacted by delay. The time-delay caused by the transport and processing of chemical components and signals may be of significant consequence. Biological systems present a challenge to model, analyze and predict. The utilization of machine learning to build mathematical models of complex systems has rapidly grown. For time-dependent series, generally a recurrent neural network (RNN), capable of returning past states, is used. In most common RNN implementations, multiple hidden layers are rebalanced during training to achieve adequate results. However, these implementations can be computationally expensive and may require extensive training data. Here, we utilize a type of RNN called an echo state network (ESN), a static, randomly initialized reservoir of nodes. We study two types of physiological systems exhibiting delay: degrade-and-fire circuits and the insulin-glucose cycle. Manipulating only signal propagation and input smoothing, we model both systems with generated reservoirs. In future works, we will further tune the reservoir, addressing stability and noise. We will also research the use of other machine learning techniques in determining the optimal parameters for reservoir generation. https://minbin.github.io/uh-surf/en-USThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).Poster