Zvolensky, Michael J.2021-08-112021-08-11December 22020-12December 2Portions of this document appear in: Smit, Tanya, Andrew H. Rogers, Lorra Garey, Nicholas P. Allan, Andres G. Viana, and Michael J. Zvolensky. "Anxiety sensitivity and pain intensity independently predict opioid misuse and dependence in chronic pain patients." Psychiatry Research 294 (2020): 113523.https://hdl.handle.net/10657/8055The United States (US) population consumes an estimated 68% of the world’s prescribed opioids each year, and over 2 million adults in the US suffer from an opioid use disorder. Although chronic pain populations are among the highest risk segments of the general population for opioid misuse and dependence, there is little understanding of individual risk characteristics that may be related to greater risk for these outcomes among this group. The present investigation explored the concurrent role of anxiety sensitivity and pain intensity and their interaction in relation to opioid misuse and dependence among 429 adults with chronic pain (73.9% female, Mage = 38.32 years, SD = 11.07). Results revealed that both anxiety sensitivity and pain intensity were associated with opioid misuse and dependence. Pain intensity and anxiety sensitivity interacted such that for individuals with higher anxiety sensitivity, but not lower anxiety sensitivity, higher pain interference was related to more severe opioid dependence. There was no evidence of an interaction for opioid misuse. Post-hoc analyses indicated that of the lower-order anxiety sensitivity facets, physical and mental incapacitation concerns significantly contributed to variance in opioid misuse and only mental incapacitation concerns significantly contributed to variance in opioid dependence. Overall, the current findings provide support for the importance of assessing anxiety sensitivity in screening for opioid-related problems among persons with chronic pain, as it may represent a distinct pathway to poorer opioid-related outcomes among this group.application/pdfengThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. UH Libraries has secured permission to reproduce any and all previously published materials contained in the work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).chronic painanxiety sensitivityopioid misuseopioid dependence2021-08-11Thesisborn digital