2020-12-162020-12-16197412578093https://hdl.handle.net/10657/7151Keonate rats were intubated dally from 0-29 days of age with 1-phenylalanlne plus dl-parachlorophenylalanlne in order to produce an animal model of phenylketonuria (PKU). On the 29th day of intubation, the PKU group had elevated plasma phenylalanine and tyrosine levels and reduced body and brain weights as compared to an agar control group. At 85 days of age the PKU animals made significantly fewer bar presses than the agar controls, with the largest difference occurring when the subjects were shifted from a CRF to a DRL-5" schedule of reinforcement. The rats were decapitated at 330 days of age and the PKU animals had significantly less DNA and wet brain weight than the agar controls in the cerebellum only. Early drug treatment of the PKU animals produced behavioral, biochemical, and neurological characteristics that resemble those of human PKU.application/pdfenThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. §107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.PhenylketonuriasPhenylalanineChlorophenylalanineThesisreformatted digital