Larin, Kirill V.Goh, MeganLiu, Chih-HaoSingh, ManmohanRaghunathan, Raksha2018-02-272018-02-272017-10-12http://hdl.handle.net/10657/2475Current diagnostic methods are able to detect severe brain trauma but are unable to detect the microscopic brain injuries that regularly occur during a concussion. Our research aims to explore a potential alternative method to detect a wider range of severity in concussions through comparing the changes in the biomechanical properties of pre- and post-concussed brain tissue using optical coherence elastography (OCE). This study is a proof of concept to see if OCE can distinguish different regions within the brain based on biomechanical properties. In this study, we hope to distinguish the hippocampus, a complex structure located in the medial temporal part of the brain beneath the cerebral cortex, from the rest of the brain. Our results show that the hippocampus is softer than the cortex of the brain, which corresponds to currently available literature. In this study, we were able to show that OCE could detect differences in the biomechanical properties of different regions of the brain.en-USThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).Poster