Daugulis, OlafsMartinez, Andrew2022-09-222022-09-222022-04-14https://hdl.handle.net/10657/11736The strong base lithium tetramethylpiperidide (LiTMP) was used to introduce a cyclopropane moiety in a minimally functionalized molecule. This new method uses a triflate leaving group to form a carbene intermediate that reacts in a statistical fashion with any adjacent hydrogens to form the cyclopropane structure. Further experimenting with the reaction conditions for functional group tolerance will allow for more complex molecules to be modified in the future. Developing new methods to synthesize cyclopropanes would allow for late-stage modification of existing drugs or natural products to further medicinal research.en-USThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).Poster