An evaluation of morphine dependence in the rat

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dc.contributor.advisorClarke, David E.
dc.contributor.committeeMemberDriever, Carl W.
dc.contributor.committeeMemberCramer, Michael B.
dc.contributor.committeeMemberCates, Lindley A.
dc.contributor.committeeMemberKimball, Aubrey P.
dc.creatorKharode, Yogendra Progatrai
dc.date.accessioned2022-06-20T16:58:05Z
dc.date.available2022-06-20T16:58:05Z
dc.date.issued1974
dc.description.abstractA semiquantitatiye method for assessing the degree of physical dependence upon morphine in rats has been examined. A time-course measure of dependence due to repetitive and increasing daily doses of morphine was obtained between one and eleven days of treatment utilizing a narcotic antagonist to precipitate withdrawal and scoring six specific withdrawal symptoms. High starting doses of morphine produced a miximal withdrawal score after two days which remained constant until the eleventh day. However, low starting doses of morphine produced a more typical dose-effect relationship from day one through day seven. The scoring system utilized in this study was analyzed and found to be acceptable, but by no means optimal to assess the degree of morphine physical dependence. The effects upon the narcotic antagonist precipitated withdrawal score, and therefore, the degree of physical dependence upon morphine, of concomitantly administered drugs was investigated. Dextroamphetamine, apomorphine and atropine were shown to decrease the total withdrawal score whereas levoamphetamine, haloperidol and atropine methyl nitrate failed to reduce significantly the total withdrawal score. Based upon these data a hypothetical model for the development of morphine physical dependence was, proposed. Although this model appeared to hold for total withdrawal scores certain discrepancies became apparent when drug-induced effects upon individual withdrawal symptoms were analyzed. Irrespective of mechanism, the research shows a clear differential effect between the two isomers of amphetamine, which could be due to differences on central dopaminergic mechanisms.
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other13805686
dc.identifier.urihttps://hdl.handle.net/10657/9516
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleAn evaluation of morphine dependence in the rat
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Pharmacy
thesis.degree.departmentPharmacy, College of
thesis.degree.disciplinePharmacy
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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