Thermodynamic and conceptual modeling of component interactions in liquid chromatography : application to reversed-phase ion-interaction and normal phase systems

dc.contributor.committeeMemberDeming, Stanley N.
dc.contributor.committeeMemberCox, James R., Jr.
dc.contributor.committeeMemberGeanangel, Russell A.
dc.contributor.committeeMemberOng, Poen S.
dc.contributor.committeeMemberWendlandt, Wesley W.
dc.creatorStranahan, John
dc.date.accessioned2023-12-07T16:12:27Z
dc.date.available2023-12-07T16:12:27Z
dc.date.issued1982
dc.description.abstractA novel pulse technique in which ion-interaction reagent is added to the column in pulses rather than constantly present in the eluent is given. A method for optimizing a separation with the pulse technique is demonstrated. A general model based upon interactions among eluent and sample components is then proposed to explain the appearance of anomalous (induced) peaks in liquid chromatography. The conceptual model is applied to explain the production of induced peaks in reversed-phase ioninteraction chromatography. A quantitative, four-parameter thermodynamic model that assumes Langmuir adsorption of an added, charged surfactant (ion-interaction reagent) at the stationary phase-mobile phase interface is developed to describe retention of charged and neutral solutes in reversed-phase "ion-pair" liquid chromatography. The general interaction model and the thermodynamic model are then applied to a normal phase system.
dc.description.departmentChemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other9433738
dc.identifier.urihttps://hdl.handle.net/10657/15552
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectLiquid chromatography
dc.titleThermodynamic and conceptual modeling of component interactions in liquid chromatography : application to reversed-phase ion-interaction and normal phase systems
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentChemistry, Department of
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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