Investigating the Role of Serotonin and Ghrelin Receptors in Neurobiology

dc.contributor.advisorGilbertson, Scott R.
dc.contributor.committeeMemberMay, Jeremy A.
dc.contributor.committeeMemberTeets, Thomas S.
dc.contributor.committeeMemberColtart, Don M.
dc.contributor.committeeMemberDas, Joydip
dc.creatorYang, Yaxing 1990-
dc.date.accessioned2019-11-07T04:06:30Z
dc.date.createdAugust 2019
dc.date.issued2019-08
dc.date.submittedAugust 2019
dc.date.updated2019-11-07T04:06:30Z
dc.description.abstractDrug addiction remains a significant problem worldwide. A new treatment strategy is needed based on the lack of approved pharmacological treatment. Serotonin (5-hydroxytryptamine, 5-HT) receptors have been implicated in a wide variety of physiological functions both in the central nerve system (CNS) and in the periphery. Our research program has been focused on the control and balance of 5-HT2AR and 5-HT2CR systems. It has been shown that these two receptors are in oppositional control with 5-HT2AR antagonists and 5-HT2CR agonists exerting similar effects on behaviors such as impulse control and reactivity to cues. The existence of the homo and heterodimers of 5-HT2AR with 5-HT2CR may play a role in differentiating signaling in this GPCR system. Accumulating data also indicate that function cross-talk between 5-HT2CR and GHS-R1a (growth hormone secretagogue receptor), and the interaction between 5-HT2CR and GHS-R1a would be a new research field to investigate. Chemistry to access bivalent ligands for the system 5-HT2AR and 5-HT2CR or 5-HT2CR and GHS-R1a, as well as ligands attached to cholesterol and serotonin will be discussed.
dc.description.departmentChemistry, Department of
dc.format.digitalOriginborn digital
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10657/5313
dc.language.isoeng
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.subjectSerotonin receptor
dc.subjectGhrelin receptor
dc.titleInvestigating the Role of Serotonin and Ghrelin Receptors in Neurobiology
dc.type.dcmiText
dc.type.genreThesis
local.embargo.lift2021-08-01
local.embargo.terms2021-08-01
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentChemistry
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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