# A study on the stability of a hyperalimentation solution stored in a polyvinyl chloride plastic bag at 5 [plus-minus] 2Â° C. and 25 [plus-minus] 2Â° C. for 0, 9, 18, and 36 hours

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In the past thirty years there has been an ever increasing use of hyperalimentation solutions. The stability of these hyperalimentation solutions has been of interest to the medical professions. Recently these hyperalimentation solutions have been dispensed and stored, for various lengths of time, in polyvinyl chloride plastic bags. Many investigators have studied the changes that can and/or do occur when medicinal agents are stored in polyvinyl chloride plastics. Hyperalimentation solutions vary in formulation but many consist of four basic ingredients: protein hydrolysate, glucose, sodium chloride, and potassium chloride. The objective of this research was to explore the possibility of reactions which can and/or do occur in a polyvinyl chloride plastic bag when a hyperalimentation solution is stored in it. The solution studied was one which is often prescribed at the Veterans Adminlstration Hospital, Houston, Texas. It was stored at 5 [plus-minus] 2Â° C. and 25 [plus-minus] 2Â° C. for 0, 9, 18, and 36 hours. The analyses performed on the hyperalimentation solution at each storage time interval were: nitrogen content, chloride ion content, glucose content, pH, and. light transmittance. Nitrogen content appeared to decrease in the solution stored at 5 [plus-minus] 2Â° C. and 25 [plus-minus] 2Â° C. for 9, 18, and 36 hours. There appeared to be a greater decrease in nitrogen content in the hyperalimentation solution stored at 25 [plus-minus] 2Â° C. There appeared to be a decrease in chloride ion content in the hyperalimentation solution stored at 5 [plus-minus] 2Â° C. and 25 [plus-minus] 2Â° C. for 9 hours, but an increase in chloride ion content stored at 5 [plus-minus] 2Â° C. and 25 [plus-minus] 2Â° C. for 13 and 36 hours. The glucose content of the hyperalimentation solution appeared to decrease after the 9 hour storage time interval at 5 [plus-minus] 2Â° C. and at 25 [plus-minus] 2Â° C. The glucose content appeared to increase after the 18 and 36 hour storage time interval. The pH of the hyperalimentation solution stored at 5 [plus-minus] 2Â° C. appeared to increase but there was no change in the solution stored at 25 [plus-minus] 2Â° C. Per cent light transmittance appeared to decrease with the storage time interval in the solutions stored at 25 [plus-minus] 2Â° C., but there was little or no change in the solution stored at 5 [plus-minus] 2Â° C. A two-way analysis of variance indicated all the changes which occurred within the hyperalimentation solution were statistically significant using a significance level of 0.05. These statistical differences, however, may not necessarily be clinically significant.