Multidrug Resistance Mechanisms in High-Grade Serous Ovarian Cancer: Literature Review

High-grade serous ovarian cancer (HGSOC) is one of the deadliest cancers for women. The standard care for the disease is the administration of paclitaxel and carboplatin chemotherapy drugs. However, almost 80% of the patients come back with recurrent, resistant disease. Also, similar polyresistance profiles among the patience suggest finding ways to solve the recurrent problem. Therefore, analyzing the most prominent and common signaling pathways specifically expressed by HGSOC resistant clones is essential to understand resistance. This literature review poster discusses current treatment methods, currently known resistance pathways, and potential treatment methods for the future, aiming to find the most effective way to prevent resistance in HGSOC.