Urinary excretion kinetics of platinum in patients following the administration of Cis-diamminedichloroplatinum (II)

Cis-diamminedichloroplatinum (II) (Cis-DDP) is a relatively new chemotherapeutic agent used in the treatment of human neoplasms. This agent has proven to be especially effective in the treatment of testicular carcinoma. The main toxicities encountered with the use of Cis-DDP are nephrotoxicity, hematopoietic toxicity and ototoxicity. The nephrotoxicity is the most serious and it is the main dose limiting factor. The purpose of the present study was to monitor parameters used for assessing toxicities and to determine the urinary excretion halflife of platinum following the administration of Cis-DDP. The purpose was also to determine, if possible, what effect prehydration and mannitol diuresis had on these values as compared to previous studies. The present study was conducted at a 314-bed cancer research hospital dedicated to research into and the treatment of neoplastic diseases. The study population included seven inpatients. Two of the patients received two consecutive courses of Cis-DDP during the study; therefore, a total of nine sets of laboratory and pharmacokinetic data were analyzed. Urine samples were obtained prior to, during and following Cis-DDP administration for 30 hours. These samples were analyzed using atomic absorption spectrophotometry. [...]