Elimination of one bond modulations and direct responses in long range heteronuclear 2D-NMR chemical shift correlation spectroscopy

dc.contributor.advisorMartin, Gary E.
dc.contributor.committeeMemberCates, Lindley A.
dc.contributor.committeeMemberAlam, Maktoob
dc.contributor.committeeMemberDyckes, Douglas F.
dc.creatorSalazar, Miguel
dc.date.accessioned2024-01-10T20:42:10Z
dc.date.available2024-01-10T20:42:10Z
dc.date.issued1987
dc.description.abstractModulation of protonated carbon response intensity in long range heteronuclear 2D-NMR chemical shift correlation spectra is discussed. Expressions describing the one bond modulation of response intensity of the C3 methylene resonance of 6,7-dimethoxy-3,4- dihydroisoquinoline and the decoupling of this modulation afforded by a BIRD pulse located midway through the A2 refocusing delay are presented with experimental confirmation. Modified long range heteronuclear chemical shift correlation pulse sequences which incorporate low pass J filters and a combination of low pass J filters and BIRD pulses are also described. In addition to eliminating one bond respones, a one step low pass J-filter is shown to partially decouple one bond modulations when incorporated in the normal long range heteronuclear chemical shift correlation pulse sequence. One and three step low pass J-filters, when utilized in combination with a BIRD pulse located midway through the refocusing delay A21 eliminate responses due to directly attached protons over a range of one bond coupling constants. The inclusion of the J-filter does not adversely affect the ability of the BIRD pulse to decouple one bond modulations. Three step J-filters were observed to produce unacceptable numbers of artifacts.
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other17473471
dc.identifier.urihttps://hdl.handle.net/10657/15857
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectNuclear magnetic resonance spectroscopy
dc.titleElimination of one bond modulations and direct responses in long range heteronuclear 2D-NMR chemical shift correlation spectroscopy
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Pharmacy
thesis.degree.departmentMedicinal Chemistry and Pharmacognosy, Department of
thesis.degree.disciplinePharmacy
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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