Evaluation of Alzheimer's disease and multi-infarct dementia with magnetic resonance imaging



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Magnetic Resonance Imaging findings in 25 patients with Senile Dementia of the Alzheimer's Type (SDAT) and 25 patients with multi-infarct dementia (MID) of similar age, sex, and levels of cognitive impairment were studied. These results indicated that SDAT patients could be differentiated from the MID patients using a multivariate combination of several different MRI measures including the lateral ventricle to brain ratio (VBR), presence of sub-cortical infarcts (sub), bi-frontal ratio (BFR), bi-caudate ratio (BCR), third ventricle ratio (3VR), and diffuse periventricular white matter lucencies (PVWL). Discriminant Function classification analysis resulted in 84% of the MID patients and 92% of the SDAT patients and 88% of the total cases correctly classified. A reduced equation utilizing the four best predictor variables of VBR, subcortical infarcts, BFR, and BCR resulted in 88% of SDAT and 76% MID patients correctly classified. A jackknife cross-validation of the prediction model resulted in 84% MID and 76% SDAT correctly classified with 80% correctly predicted overall. Univariate comparisons of the SDAT and MID patients demonstrated the groups significantly differed on VBR, subcortical infarcts, BFR, and BCR. In summary, the SDAT patients had more marked ventricular dilation on all atrophy measures than the MID patients whereas the MID patients displayed a higher frequency of focal ischemic changes and diffuse white matter hyperintensities.



Dementia, Senile dementia, Alzheimer's disease, Cerebrovascular disease