Effects of CI-933 on attention and memory in normal human volunteers

The effect of a new drug, CI-933, on attention and memory in twelve healthy normal volunteers was investigated. The subjects, seven males and five females, ranged in age from 40 to 71 and their level of education ranged from 12 to 18 years. They received placebo and three doses of CI-933 in a Latin square design so that the sequence of the drug was counterbalanced. Fifty minutes after Ingestion of the drug the subjects underwent neuropsychological testing. The test battery was comprised of the Paced Auditory Serial Addition Test, the Seashore Rhythm, the Digit Cancellation, the Digit Span subtests from the WAIS-R, and the Buschke Selective Reminding Test. Multivariate analysis of the data using orthogonal polynomials to assess dose response yielded nonsignificant results.