Aptamer Based Organic Electrochemical Transistor for Sensitive and Selective Epinephrine Detection

The goal of this project was to detect epinephrine in concentrations less than 1 nM. Detection of epinephrine (aka. adrenaline) has significance in a variety of applications: from anti-doping regulations in sports to lifesaving treatments for cardiac arrest or allergic reactions. Organic electrochemical transistors (OECTs) display signal amplification; a small change in gate voltage induces a large change in channel current. Aptamers display good selectivity in binding to biomolecules. By combining these two aspects, we hope to develop a highly sensitive and selective method for the detection of epinephrine. This project was completed with contributions from Sudipta Seal, Nileshi Saraf, and Madison Peppler from the Department of Materials Science and Engineering, University of Central Florida.