The stability of phenylephrine hydrochloride in intravenous solutions

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1969

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The stability of Phenylephrine Hydrochloride in intravenous solutions was studied. Stability tests were conducted on six different formulations at three different temperatures (.22°, 45°, and 60° C.) for a period of 84 days. The intravenous solutions used were Normal Saline and Five per cent Dextrose in water. It was found that Phenylephrine Hydrochloride appeared to be stable in each of the above solutions alone, as well as in the presence of Chloramphenicol Succinate or Potassium Chloride. However, decomposition of Phenylephrine Hydrochloride was noted at 45° and 60° C., when Sodium Bicarbonate was present. The rate of decomposition of Phenylephrine Hydrochloride appears to be a first order reaction and the energy of activation was calculated to be 8.0 kilocalories per mole.

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