Studies in nitration of thiochroman

dc.contributor.advisorMcElrath, Eby
dc.contributor.committeeMemberGraves, Leon F.
dc.contributor.committeeMemberDrake, C. E.
dc.contributor.committeeMemberFan, Joyce Wang
dc.creatorMcLean, Hugh E.
dc.date.accessioned2022-06-22T19:53:39Z
dc.date.available2022-06-22T19:53:39Z
dc.date.issued1952
dc.description.abstractThiochroman is a light yellow highly refractive oil, which was prepared frist in 1905 by Von Braum by reacting potasium ethyl zanthate and the diaso salt of o-([gamma]-chloropropyl-)anilin. A second method of synthesis was discovered in 1923 by krollpfeiffer and Schults, who oxidized [beta]-phenlmercaptopropionic acid with concentrated sulfuric acid to thiochromanone and reduced the thiochromanone by the Clemenson method to thiochroman. The following compounds were prepared by this method: 6-methylthiochroman; 6,8-dimethylthiochroman; 7,8-benzothiochroman; and 5,6-benzothiochroman. In 1946 Cagniant and Deluserche prepared acyl dreivatives by direct substitution. In 1950 Cagniant and Cagniant prepared 6-bromothiochroman by direct substitution, and from this compound they prepared 6-cyanthiochroman, 6-carboxythiochroman, and 6-acetylthiochroman. The purpose of this investigation was to determine which of the two methods of synthesis was most suitable for the preparation of large quantities of Thiochroman, and to clarify the orientation in the thiochroman nucleus by the study of its nitration reactions...
dc.description.departmentChemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other13726297
dc.identifier.urihttps://hdl.handle.net/10657/9882
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleStudies in nitration of thiochroman
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Arts and Sciences
thesis.degree.departmentChemistry, Department of
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Houston
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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