Electrochemistry and spectroelectrochemistry of iron porphyrins and other biological redox components

Date
1984
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Abstract

The electrochemistry of several biological redox components was investigated in non-aqueous solvents. Special emphasis was reserved to iron porphyrins. The general aim of this work was to study models for the inhibition or destruction of some biological metabolisms. Nitric oxide can almost irreversibly complex hemoglobin and the presented electrochemical study of axially bound nitric oxide iron porphyrins gave additional proof for the stability of this complex. It can undergo five electron-transfer reactions without any NO displacement. Furthermore, the presented potential for Fe(II)ZFe(III) oxidation is one of the most anodic ever reported for similar species. Metabolism of some organic substrates by cytochrome P-450 can result in the heme destruction. [...]

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Keywords
Porphyrins, Oxidation-reduction reaction
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