Comparison of Outcomes of Preterm Infants Who Received Human Milk-Based vs. Bovine-Milk Based Human Milk Fortifier

dc.contributorAgan, Herb
dc.contributorUnger, Jana
dc.contributorHagan, Joseph
dc.contributorPremkumar, Muralidhar
dc.contributorHair, Amy B.
dc.contributor.authorGovande, Janhavi
dc.description.abstractBackground: Bovine (BOV) or human milk-based fortifier (HUM) is used to add necessary macronutrients to mother's own breastmilk. HUM has been shown to improve growth outcomes and decrease morbidities in infants<1250 grams (g) birth weight (BW). Data is scant about outcomes for neonates 1250-1500g BW. Aim: Compare neonatal outcomes of infants 1250-1500g BW fed HUM vs BOV. Methods: This retrospective cohort study examined data from 150 babies 1250-1500g BW born Jan. 2016-Dec. 2018. Nutrition outcomes included days to full feeds (130 mL/kg/day), parenteral nutrition days, weight, length, and head circumference data. Nutritional z-scores were calculated using Fenton 2013 curves. Clinical outcomes included common neonatal morbidities. Outcomes were analyzed through statistical testing. Comparisons were adjusted for BW. Results: HUM-fed infants were born earlier, had a lower BW, and lower % of small for gestational age (SGA) infants at birth. The postmenstrual age (PMA) at discharge was not significantly different. HUM-fed infants had higher discharge weight z-score and growth velocity. Conclusions: Despite being more premature and smaller at birth, HUM-fed infants went home at a similar PMA and had less postnatal growth failure. This study demonstrates a HUM diet is associated with improved growth outcomes for infants 1250-1500 g BW. This project was completed with contributions from Jana Unger, Joseph Hagan, Muralidhar Premkumar, and Amy B. Hair from the Texas Children's Hospital.
dc.description.departmentBiology and Biochemistry, Department of
dc.description.departmentHonors College
dc.rightsThe author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).
dc.titleComparison of Outcomes of Preterm Infants Who Received Human Milk-Based vs. Bovine-Milk Based Human Milk Fortifier


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