Synthetic approaches to a fluorine derivative of carazolol

dc.contributor.advisorWeinheimer, Alfred J.
dc.contributor.advisorTewson, Timothy J.
dc.contributor.committeeMemberLemke, Thomas L.
dc.contributor.committeeMemberFuchs, Richard
dc.creatorHe, Yi Fang
dc.description.abstractThe objective of this study was to develop a synthesis of a fluorine containing derivative of the beta-adrenergic blocking agent, carazolol. The method could then be employed to synthesize the isotopically labelled analog of the derivative containing the positron emitting 18F for use in quantification of beta-adrenergic receptors in cardiac tissue. The synthetic approach involved introduction into the unsubstituted ring of 4-carbazolol of a small aliphatic side chain for incorporation of a fluorine atom. The tosylate derivative was used both to protect the phenol and to direct substitution into the non-oxygenated ring. It was found that substitutions occurred only at the nitrogen atom of the carbazole nucleus. When this position was blocked by acetylation, no substitution products were found. A third variant of this approach is suggested for further work.
dc.description.departmentPharmacy, College of
dc.format.digitalOriginreformatted digital
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectAdrenergic beta blockers
dc.titleSynthetic approaches to a fluorine derivative of carazolol
dc.type.genreThesis of Pharmacy, College of of Houston of Science


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