The synthesis of thiosemicarbazone derivatives of 5,6,7,8-Tetrahydro-8-quinolone

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1975

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Abstract

Thiosemicarbazones of pyridine-2-carboxaldehyde, as well as those of isoquinoline-1-carboxaldehyde, have been investigated, and some have been demonstrated to possess carcinostatic activities when tested on mouse tumor systems. 5,6,7,8-Tetrahydro-8-quinolone, a novel heterocyclic ketone system, was prepared and its thiosemicarbazone derivatives are postulated to have antitumor activities according to the presently known structure-activity relationships. Three thiosemicarbazones of the 5,6,7,8-tetrahydro-8-quinolone were synthesized, namely 3'-thiosemicarbazone, 4'-methyl-3'-thiosemicarbazone and 4'-allyl-3'-thiosemicarbazone. Preliminary screening of these compounds for antineoplastic activities will be performed to determine whether the thiosemicarbazones of this new ring system warrant any further studies.

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