A prospective study of the epidemiology of adverse drug reactions in pediatric hematology and oncology patients

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1973

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A Prospective Study of the Epidemiology of Adverse Drug Reactions in Pediatric Hematology and Oncology Patients. Collins, George E., B.S., University of Texas at Austin; College of Pharmacy, 1971. M.S., University of Houston, 1973. Thesis directed by Michael M. Clay, Ph.D., Professor of Pharmacology. This study has been concerned with the epidemiology of adverse drug reactions in pediatric hematology and oncology patients in a 181 bed pediatric teaching hospital. An attempt was made to determine the effect of such reactions in these patients and to measure their relationship to specific patient and drug characteristics. A Pharmacist-Monitor was used to coordinate the collection of reaction data with a team of physicians and nurses. Sixty-three patients were included in this study. Thirty-five or 56 per cent, of these patients acquired at least one adverse drug reaction while hospitalized. Ninety-one reactions were hospital-acquired to 23 different drugs. Seventeen admissions were a direct result of a drug reaction, while adverse drug reactions were detected in another 35 admissions. An increased risk of having an adverse drug reaction was shown in those admissions receiving more drugs and who had a prior history of an adverse drug reaction. 108 The results of this study suggest that, the concept of a pharmacist monitoring patients for adverse drug reactions is successful. The results also suggest that more attention be given to the examination of adverse drug reactions in the pediatric patient.

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