Detectable Vancomycin Stool Concentrations in Hospitalized Patients with Diarrhea Given Intravenous Vancomycin

dc.contributor.authorEubank, Taryn A.
dc.contributor.authorHu, Chenlin
dc.contributor.authorGonzales-Luna, Anne J.
dc.contributor.authorGarey, Kevin W.
dc.date.accessioned2023-12-22T13:45:04Z
dc.date.available2023-12-22T13:45:04Z
dc.date.issued2023-09-28
dc.date.updated2023-12-22T13:45:05Z
dc.description.abstractVancomycin is not appreciably passaged via the colonic membrane to the gastrointestinal (GI) tract in persons with an intact gut epithelium due to its large chemical structure. However; hospitalized patients with diarrhea often have a disrupted GI tract. The aim of this study was to determine the frequency of detectable vancomycin concentrations in the stool of patients with antibiotic-associated diarrhea receiving IV vancomycin. This was a multicenter cohort study of hospitalized patients with stool samples collected for <i>Clostridioides difficile</i> testing. Leftover stool samples were collected from patients who had received at least 3 days of IV vancomycin. Fecal vancomycin was quantified by high-performance liquid chromatography. The study cohort included 33 unique patients, majority female (54.5%) aged 60 years (range 23&ndash;84). Eighteen of thirty-three patients (54.5%) tested positive for <i>C. difficile</i> toxins. The average duration of systemic vancomycin administration prior to stool collection was 3.5 (range 2&ndash;15) days. Three of 33 (9%) stool samples had a detectable vancomycin concentration (range 1.2&ndash;13.2 mcg/mL). These concentrations may promote the development of vancomycin-resistant <i>Enterococcus</i> or van mutations in <i>C. difficile</i>, leading to vancomycin resistance. Further studies on implications are warranted.
dc.identifierdoi: 10.3390/pharma2040024
dc.identifier.citationPharmacoepidemiology 2 (4): 283-288 (2023)
dc.identifier.urihttps://hdl.handle.net/10657/15674
dc.titleDetectable Vancomycin Stool Concentrations in Hospitalized Patients with Diarrhea Given Intravenous Vancomycin

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