The Effect of Alcohol and Cannabinoids on the Microvasculature in Embryonic Brain

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2023-04-13

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Abstract

Fetal alcohol spectrum disorder (FASD) is a spectrum of psychological and physical disorders that can lead to diseases in the central nervous system, such as Parkinson’s disease, Alzheimer’s disease, and/or amyotrophic lateral sclerosis, physical defects, like cleft lip, vision and hearing problems, smaller head and brain size, and social and behavioral issues, such as social anxiety and attention deficit hyperactivity disorder. This study aims to assess the acute effects of a combination of alcohol and a synthetic cannabinoid on the embryonic brain vasculature. The study will be broken down into three separate experimental setups: alcohol, synthetic cannabinoids, and a mixture of alcohol and synthetic cannabinoids. Using angiographic optical coherence tomography, the main vessel of the brain of the murine embryo will be monitored for changes after the administration of the respective substance. The vessel diameter in the main brain vessel decreases within the first 10 minutes of the administration of the alcohol, and the effect persists through the 45 minutes. The experimental setup for administering synthetic cannabinoids and then a mixture of alcohol and synthetic cannabinoids are in progress. The results conclude that the ingestion of alcohol by the mother constricts blood flow in the embryo's brain.

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Public Health, Data and Society

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