Nucleoside monophosphate pools in BU-induced filaments of Escherichia coli K-12

dc.contributor.advisorJones, Roosevelt J.
dc.contributor.committeeMemberBartel, Allen H.
dc.contributor.committeeMemberEvans, John E.
dc.contributor.committeeMemberKimball, Aubrey P.
dc.contributor.committeeMemberMann, James E.
dc.contributor.committeeMemberAumann, Glenn David
dc.creatorThompson, Dorothy Pierre
dc.date.accessioned2022-06-20T16:58:02Z
dc.date.available2022-06-20T16:58:02Z
dc.date.issued1974
dc.description.abstract5-Broznouracil (BU) caused qualitative and quantitative changes in the nucleoside monophosphate pools in Escherichia coli Thy - His - which had been previously starved for histidine. The changes in the nucleoside monophosphate pools were apparent as early as 120 minutes during BU-incubation. When cells were grown in the presence of 32Pi, NAD, AMP, CMP, dADP, were not detected. There was a significant increase in GMP, UMP CDP, dCDP, and TMP. The "weakly-binding" BU-compound, was found to be a dinucleoside monophosphate and when subjected to phosphodiesterase yielded 5-BUR and '5-AMP. The dinucleoside monophosphate is probably a catabolic product or RNA. 2-14C-5-BU was incorporated into RNA.
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other23173142
dc.identifier.urihttps://hdl.handle.net/10657/9513
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleNucleoside monophosphate pools in BU-induced filaments of Escherichia coli K-12
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentBiology, Department of
thesis.degree.disciplineBiology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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