Effect of formulation variables on the release of meprobamate from compressed tablets

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1972

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Abstract

The influence of formulation variables on the dissolution rate of Meprobamate tablets has been investigated. Tablets containing 200 mg. of Meprobamate were prepared using a variety of ingredients as tablet excipients. The dissolution rates of the resulting tablets were determined using a modified USP XVIII procedure. Meprobamate was determined by a colorimetric assay. Disintegration times were determined using a USP Tablet Disintegration Tester. Several variables were changed at the same time, and regression analysis was performed on the resulting data. Lactose and corn starch, when used as diluents for Meprobamate tablets, exhibited a fast dissolution rate. Sucrose and mannitol seem to be less effective than lactose or corn starch as tablet diluents. Aerosil[registered trademark] cannot be used as a diluent for Meprobamate tablets since it interferes with the production of a good tablet. As binders for Meprobamate tablets, starch paste seems to be the best followed by gelatin solution. Acacia increased the dissolution rate of Meprobamate tablets when used as a disintegrator. Acacia was followed, in the order of effectiveness by starch, Aerosil[registered trademark], and microcrystalline cellulose. Magnesium stearate seems to be a good lubricant for Meprobamate tablets; it was more effective than either talc or sodium lauryl sulfate. The dissolution rate of Meprobamate tablets seems to be a function of the interactions between the various ingredients rather than of a single ingredient. The dissolution rate of Meprobamate tablets appears to be related to the hardness of the tablets. However, the dissolution rate is not directly related to the disintegration time.

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