Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists

dc.contributor.authorChung, Sang-Hyuk
dc.contributor.authorLambert, Paul F.
dc.date.accessioned2020-03-10T17:11:51Z
dc.date.available2020-03-10T17:11:51Z
dc.date.issued11/17/2009
dc.description.abstractThe majority of human cervical cancers are associated with the high-risk human papillomavirus (HPV) types. In mouse models for HPV-associated cancers, estrogen is required for the development of cervical and vaginal cancers. The estrogen receptor ? (ER?) also is required in mice for these cancers to arise. These data are consistent with the observation in women that long-term use of oral contraceptives or multiple pregnancies significantly increases the risk for cervical cancer in HPV-positive women. In the present study, we examined whether drugs that interfere with the function of ER? are effective in treating and/or preventing cervical cancer in mice. We provide evidence that a complete ER antagonist, ICI 182,780 (ICI), as well as a selective ER modulator, raloxifene, efficiently clear cancer and its precursor lesions in both the cervix and the vagina. Furthermore, ICI was capable of preventing the onset of cancers in mice bearing precursor lesions. These findings point to the potential value of ER antagonists in controlling gynecological disease in the lower reproductive tracts in women.
dc.identifier.citationCopyright 2009 Proceedings of the National Academy of Sciences. Recommended citation: Chung, Sang-Hyuk, and Paul F. Lambert. "Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists." Proceedings of the National Academy of Sciences 106, no. 46 (2009): 19467-19472. DOI: 10.1073/pnas.0911436106 URL: https://www.pnas.org/content/106/46/19467. Reproduced in accordance with the original publisher's licensing terms and with permission from the author(s).
dc.identifier.urihttps://hdl.handle.net/10657/5916
dc.language.isoen_US
dc.publisherProceedings of the National Academy of Sciences
dc.subjectcervix
dc.subjectpapillomavirus
dc.subjectHPV
dc.subjectSERM
dc.subjectcervical cancer
dc.subjectestrogen
dc.titlePrevention and treatment of cervical cancer in mice using estrogen receptor antagonists
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Chung_2009_Preventionandtreatmentof.pdf
Size:
1.84 MB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.69 KB
Format:
Plain Text
Description: