Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists

Date

11/17/2009

Journal Title

Journal ISSN

Volume Title

Publisher

Proceedings of the National Academy of Sciences

Abstract

The majority of human cervical cancers are associated with the high-risk human papillomavirus (HPV) types. In mouse models for HPV-associated cancers, estrogen is required for the development of cervical and vaginal cancers. The estrogen receptor ? (ER?) also is required in mice for these cancers to arise. These data are consistent with the observation in women that long-term use of oral contraceptives or multiple pregnancies significantly increases the risk for cervical cancer in HPV-positive women. In the present study, we examined whether drugs that interfere with the function of ER? are effective in treating and/or preventing cervical cancer in mice. We provide evidence that a complete ER antagonist, ICI 182,780 (ICI), as well as a selective ER modulator, raloxifene, efficiently clear cancer and its precursor lesions in both the cervix and the vagina. Furthermore, ICI was capable of preventing the onset of cancers in mice bearing precursor lesions. These findings point to the potential value of ER antagonists in controlling gynecological disease in the lower reproductive tracts in women.

Description

Keywords

cervix, papillomavirus, HPV, SERM, cervical cancer, estrogen

Citation

Copyright 2009 Proceedings of the National Academy of Sciences. Recommended citation: Chung, Sang-Hyuk, and Paul F. Lambert. "Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists." Proceedings of the National Academy of Sciences 106, no. 46 (2009): 19467-19472. DOI: 10.1073/pnas.0911436106 URL: https://www.pnas.org/content/106/46/19467. Reproduced in accordance with the original publisher's licensing terms and with permission from the author(s).