The effect of vitamin E on the incidence and severity of retinopathy of prematurity



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A study to evaluate the efficacy of vitamin E in reducing the incidence and severity of retinopathy of prematurity (ROP) was performed at the Texas Children's Hospital, Houston, Texas. One hundred and one premature infants weighing 1500 grams or less, and requiring respiratory support, were included in the study. The infants received either the control (5mg/kg/day) or experimental (1OOmg/kg/day) dosage of vitamin E on the basis of a random number table. Serum vitamin E levels were obtained from blood collected on an assigned schedule and a clear dichotomy in serum E (6pg/ml versus 12pg/ml) was apparent between control and experimental populations. The grades of retinopathy were evaluated by indirect Opthalmoscopy (McCormick Classification) beginning the third week of life and continuing weekly throughout the infants' hospital stay. [...]



Retina--Diseases, Vitamin E--Therapeutic use