Cerebral cortical somatostatin and cognitive dysfunction in Alzheimer's disease

dc.contributor.advisorSheer, Daniel E.
dc.contributor.committeeMemberPirozzolo, Francis J.
dc.contributor.committeeMemberDoughtie, Eugene B.
dc.contributor.committeeMemberBuffum, William E.
dc.creatorSwihart, Andrew A.
dc.date.accessioned2023-12-08T20:57:38Z
dc.date.available2023-12-08T20:57:38Z
dc.date.copyright1987-09-17
dc.date.issued1986
dc.description.abstractThis study investigated the relationship between cerebral cortical somatostatinergic activity and neuropsychological dysfunction in Alzheimer's disease. Somatostatin-like immunoreactivity was determined in frontal lobe cortical biopsy samples obtained from five Alzheimer's disease patients. Prebiopsy quantification of the following neuropsychological variables was performed: global cognitive decline; verbal, nonverbal and full-scale intelligence; verbal and visual memory; language; visual perceptual discrimination and organization; simple auditory, simple visual, and four choice visual reaction time; and attention and concentration ability. The association between cortical somatostatinergic activity and these various neuropsychological functions was explored via the calculation of Spearman's rank-difference correlation (Rho). Findings are discussed within the context of: (a) the so-called "cholinergic hypothesis" of Alzheimer's disease, and (b) recent reconceptualizations of Alzheimer's disease as a primary cortical disease.
dc.description.departmentPsychology, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other17154365
dc.identifier.urihttps://hdl.handle.net/10657/15586
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.subjectAlzheimer's disease--Physiological aspects
dc.subjectSomatostatin
dc.titleCerebral cortical somatostatin and cognitive dysfunction in Alzheimer's disease
dc.type.dcmiText
dc.type.genreThesis
dcterms.accessRightsThe full text of this item is not available at this time because it contains documents that are presumed to be under copyright and are accessible only to users who have an active CougarNet ID. This item will continue to be made available through interlibrary loan.
thesis.degree.collegeCollege of Liberal Arts and Social Sciences
thesis.degree.departmentPsychology, Department of
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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