Rate of self-stimulation and certain temporal parameters of double-pulse stimulation



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Pairs of 0.1 msec. d.c. pulses were delivered in 0.65 sec. trains to the medial forebrain bundle of 6 rats in a study of self-stimulation. The interval between pulses in a pair was modified within the range of 2 msec, to 0 msec, and the effect of these modifications on rate of self-stimulation was examined. It was found that response rate was at a minimum when pulse separation was 0.3 msec. Average response rate across subjects increased monotonically as pulse separation increased from 0.3 to 1.2 msec. and as separation decreased from 0.3 to 0 msec. The results are interpreted as supporting Deutsch's hypothesis regarding double pulse stimulation and the post-stimulation excitability cycle of neurons in the lateral hypothalamus.



Electric stimulation, Brain stimulation