Pharmacokinetic investigation of phenprobamate in rats

Date
1988
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Abstract

An HPLC procedure for the assay of phenprobamate, a skeletal muscle relaxant, in biological fluids was developed. The method used a C18 reverse phase column, a mobile phase of methanol/acetonitrile/water (33 : 15 : 52), and UV detection at 215 nm. The analysis procedure was applied to the determination of protein binding, RBC/plasma partitioning and pharmacokinetics of phenprobamate. [...]

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Keywords
Muscle relaxants--Physiological effect, Pharmacokinetics
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