ASSOCIATION BETWEEN HEART FAILURE AND HAND SENSORIMOTOR FUNCTION

Date

2022-12-01

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Heart failure (HF) is a complex syndrome characterized by structural or functional defects of ventricular filling or ejection fractions of the heart that do not meet metabolic requirements. While dyspnea, fatigue, and fluid retention are symptoms commonly reported by persons with HF (PwHF), indispensable reports demonstrating declined independence in activities of daily living (ADLs) are also mounting. Yet, the underlying mechanism(s) of declined functional independence in PwHF is unknown. The purpose of this study is to investigate potential causes of declined functional independence in PwHF by comparing hand sensorimotor function and attentional capacity in PwHF and age- and sex-matched control subjects. Additionally, the study examines whether the severity of HF is associated with hand sensorimotor function and attentional capacity. A total of 10 age- and sex-matched control subjects (58.2 ± 12.2 years old, 6 men) and 10 PwHF (57.6 ± 12.5 years old, 6 men) were recruited. Hand sensorimotor function was evaluated through Semmes-Weinstein monofilament test, nine-hole peg test (9HPT), and constant pinch force tracking test. Attentional capacity was quantified by delivering a dual-tasking paradigm and calculating the dual-tasking cost in constant pinch force tracking test and n-back test. Finally, the total walking distance in 6-minute walk test (6MWT) was measured to determine the severity of HF. While the level of independence was comparable between healthy control subjects and PwHF, reduced hand motor function was observed in PwHF as the performance of 9HPT and the pinch force stability while maintaining at 5% of maximal pinch force were reduced in PwHF compared healthy control subjects. Reduced hand motor function did not coincide with reduced hand sensory function and attentional capacity as the threshold of tactile registration and the value of dual-tasking cost did not differ between healthy control subjects and PwHF. Finally, the total walking distance in 6MWT did not correlate with any variables that were collected in the study. Despite the lack complaints in self-care functionality in PwHF, the study found reduced hand motor function in PwHF compared to healthy control subjects. The reduced hand motor function in PwHF may be attributed to HF-related abnormalities vii in cortical structure and cerebrovascular regulation since hand sensory function and attentional capacity were comparable between healthy control subjects and PwHF. Lack of correlation between the total walking distance in 6MWT and other variables may be due to the influence of factors unrelated to HF and small range of HF severity evaluated in this study. Our findings established a milestone for further understanding in the mechanisms of a reduced self-care functionality among PwHF.

Description

Keywords

Hand sensorimotor function, Heart failure

Citation

Portions of this document appear in: Hibino, Hidetaka, and Stacey L. Gorniak. "Dependence and reduced motor function in heart failure: future directions for well-being." Heart Failure Reviews 27, no. 4 (2022): 1043-1051.