Effect of dibutyryl cyclic AMP on the growth of B16 melanoma cells In Vitro and on the synthesis of nonhistone chromosomal protein

dc.contributor.advisorVenketeswaran, S.
dc.contributor.committeeMemberSpring, Thomas G.
dc.contributor.committeeMemberCowles, Joe R.
dc.contributor.committeeMemberEvans, John E.
dc.creatorJansing, Robert Lester
dc.date.accessioned2022-06-20T16:07:48Z
dc.date.available2022-06-20T16:07:48Z
dc.date.issued1975
dc.description.abstractDitratyryl cyclic AMP was found to cause a marked decrease in the growth rate of B16 melanoma cells in vitro. Accompanying the inhibition of growth were marked alterations in cell morphology and a decrease in agglutinability by Concanavalin A, a monitor of surface changes in the plasma membrane. Control cells reached confluency after three days incubation but continued to proliferate and eventually sloughed off into the growth medium. Cells grown in the presence of dibutyryl cyclic AMP reached confluency after four days incubation, whereupon there was a marked decrease in the growth rate. Electrophoretic banding patterns of nonhistone chromo- somal proteins revealed an increase in the synthesis of high molecular weight nonhistone proteins of cell s grown in the presence of dibutyryl cyclic AMP.
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other2438268
dc.identifier.urihttps://hdl.handle.net/10657/9423
dc.language.isoen
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. Section 107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleEffect of dibutyryl cyclic AMP on the growth of B16 melanoma cells In Vitro and on the synthesis of nonhistone chromosomal protein
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentBiology, Department of
thesis.degree.disciplineBiology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Jansing_1975_2438268.pdf
Size:
4.7 MB
Format:
Adobe Portable Document Format