Correlations of the effects of anoxic cardiac arrest on canine myocardial functions and the subcellular mitochondria

dc.contributor.advisorHuggins, Sara E.
dc.contributor.committeeMemberAumann, Glenn David
dc.contributor.committeeMemberSpring, Thomas G.
dc.contributor.committeeMemberGillette, Paul C.
dc.creatorWong, Nelson Johnston Ka-cheung
dc.date.accessioned2022-05-19T17:57:18Z
dc.date.available2022-05-19T17:57:18Z
dc.date.issued1974
dc.description.abstractMyocardial changes were studied in dogs in an attempt to correlate the effects of anoxic cardiac arrest with subcellular changes, specifically those in mitochondria. Twenty dogs were studied to determine the effects of anoxia on mitochondria in hearts with chronic outflow obstruction produced by clamping the aorta. Two animals were used as normal and two as experimental controls. Except for normal controls, all dogs were placed under complete cardiopulmonary bypass, some under normothermic and some under hypothermic conditions. After 40 minutes of aortic occlusion at 37°C, animals showed depression of left-ventricular function as indicated by profound impairment of the oxidative phosphorylation process of the mitochondria. The difference between the respiratory control rates in experimental controls and the experimentals was significant at the p<0.001 level, demonstrating that cardioplegia of 40 minutes is detrimental to the canine heart through its effect on the mitochondrial activity. This deterioration was decreased by 33% if the temperature of the perfusion blood was kept at 30°C.
dc.description.departmentBiology and Biochemistry, Department of
dc.format.digitalOriginreformatted digital
dc.format.mimetypeapplication/pdf
dc.identifier.other14077327
dc.identifier.urihttps://hdl.handle.net/10657/9152
dc.language.isoen
dc.relation.ispartofSenior Honors Theses
dc.rightsThis item is protected by copyright but is made available here under a claim of fair use (17 U.S.C. §107) for non-profit research and educational purposes. Users of this work assume the responsibility for determining copyright status prior to reusing, publishing, or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions requires express permission of the copyright holder.
dc.titleCorrelations of the effects of anoxic cardiac arrest on canine myocardial functions and the subcellular mitochondria
dc.type.dcmiText
dc.type.genreThesis
thesis.degree.collegeCollege of Natural Sciences and Mathematics
thesis.degree.departmentBiology, Department of
thesis.degree.disciplineBiology
thesis.degree.grantorUniversity of Houston
thesis.degree.levelBachelors
thesis.degree.nameBachelor of Science
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