Recurrence of cervical cancer and its resistance to progestin therapy in a mouse model

Date

11/29/2016

Journal Title

Journal ISSN

Volume Title

Publisher

Oncotarget

Abstract

Studies using K14E6/K14E7 transgenic mice expressing E6 and E7 oncoprotein of human papillomavirus type 16 (HPV16) have demonstrated that estrogen (E2) is required for the genesis and growth of cervical cancer. Our prior study using the same mouse model has showed that progestin drug medroxyprogesterone acetate (MPA) promotes regression of primary cervical cancer. In the present study, we use the same transgenic mouse model to determine whether the cancer recurs after MPA therapy. Cervical cancer recurred even if MPA treatment was continued. Unlike primary cervical cancer, the cancer recurred even in the absence of exogenous E2 when MPA treatment was ceased. Furthermore, recurrent cervical cancer did not fully regress upon MPA treatment. Our results support that MPA fails to completely eliminate primary cervical cancer cells and that remaining cancer cells grow independent of exogenous E2 and are refractory to MPA

Description

Keywords

cervical cancer, human papillomavirus, HPV, recurrence, therapy resistance, medroxyprogesterone acetate (MPA)

Citation

Copyright 2016 Oncotarget. Recommended citation: Mehta, F. F., S. Baik, and S. H. Chung. "Recurrence of cervical cancer and its resistance to progestin therapy in a mouse model." Oncotarget 8, no. 2 (2017): 2372-2380. DOI: https://doi.org/10.18632/oncotarget.13676. URL: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=13676&path[]=43462. Reproduced in accordance with the original publisher’s licensing terms and with permission from the author(s).