Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus
Date
2011-03
Journal Title
Journal ISSN
Volume Title
Publisher
Bioorganic and Medicinal Chemistry Letters
Abstract
A small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure–activity relationships and leading to the identification of targocil, a potent antibiotic.
Description
Keywords
wall teichoic acids (WTAs), staphylococcus aureus, Bacteriostatic, structure acivity relationship (SAR), triazoloquinazoline, targocil
Citation
Copyright 2011 Bioorganic and Medicinal Chemistry Letters. This is a post-print version of a published paper that is available at: https://www.sciencedirect.com/science/article/pii/S0960894X1000048X. Recommended citation: Lee, Kyungae, Jennifer Campbell, Jonathan G. Swoboda, Gregory D. Cuny, and Suzanne Walker. "Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus." Bioorganic & medicinal chemistry letters 20, no. 5 (2010): 1767-1770.This item has been deposited in accordance with publisher copyright and licensing terms and with the author's permisson.