• Login
    View Item 
    •   Repository Home
    • UH Faculty, Staff, and Student Works
    • UH Faculty, Staff, and Student Works
    • View Item
    •   Repository Home
    • UH Faculty, Staff, and Student Works
    • UH Faculty, Staff, and Student Works
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    State of the Science of Adherence in Pre-Exposure Prophylaxis and Microbicide Trials

    Thumbnail
    View/Open
    Gearing_2012_StateOfTheScienceAM.pdf (484.5Kb)
    Date
    12/01/12
    Author
    Muchomba, Felix M.
    Gearing, Robin E.
    Simoni, Jane M.
    El-Bassel, Nabila
    Metadata
    Show full item record
    Abstract
    For pre-exposure prophylaxis (PrEP) and microbicides to effectively prevent HIV, optimal treatment adherence is required. Adherence to these strategies, however, has not been sufficiently studied. This investigation systematically reviews oral PrEP and microbicide trials across 4 domains of adherence: 1) definition and measures used; 2) risks for non-adherence; 3) promotion strategies; and 4) effects on outcomes. Nineteen (n = 19) trials, with 47157 participants, published between 1987 and 2012 were identified. Reported mean adherence to microbicides was 79% and to oral PrEP 87%. Common risks for microbicide nonadherence were decreased motivation over time, sex with primary (noncommercial/casual) partners, and insufficient supply. Oral PrEP non-adherence risks were older age and medication side effects. Psychoeducation and outreach to participants and communities were frequently utilized promotion strategies. Most trials failed to systematically identify barriers and monitor and promote adherence, although adherence moderated outcomes. Recommendations for attending to adherence in future trials are provided.
    URI
    http://hdl.handle.net/10657/3029
    Collections
    • UH Faculty, Staff, and Student Works

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    TDL
    Theme by 
    Atmire NV
     

     

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsDepartmentsTitlesSubjectsThis CollectionBy Issue DateAuthorsDepartmentsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    TDL
    Theme by 
    Atmire NV