Global Structural Mechanism of Translation and Evolution of RNA towards Modern Life

The structure of the ribosome and its function is explored through superposition of published crystal structure data. “Pivoting elements” are discovered in the ribosome - structural weakness caused primarily by UG mismatches and similar motifs. This structural weakness allows for functionality in the ribosome and consequently all RNA. An overall connected network of motion is further revealed in the ribosome propagating from cofactor GTPases through the decoding center and back. The mobile network is highlighted by series of equally mobile ribosomal proteins.

A series of questions regarding the origins of life are explored through the application of dynamic combinatorial chemistry to biochemical systems. A series of experiments were proposed, defended and performed, which show that RNA can, in an aquatic environment, gain information size and become, over time, robust towards hydrolytic stress.